BCL6 & endometriosis can be related to each other. Increased BCL6 levels are associated with endometriosis, the leading cause of female infertility. BCL6 is a positive marker for silent endometriosis. High BCL6 levels indicate the presence of uterine lining inflammation.

If someone is experiencing fertility issues, knowing more about silent endometriosis and its reproductive health effects can influence their treatment journey. Here are a few facts and myths about BCL6 and endometriosis:

Fact: BCL6 Is Linked to Uterine Inflammation

BCL6 (B-cell lymphoma 6) is a human protein in the BCL6 gene linked with uterine lining inflammation. BCL6 indicates the presence of uterine inflammation. Endometriosis causes the creation of cells similar to tissue similar to the uterine lining, which causes inflammation.

BCL6 forms a complex that attaches to and disables progesterone pathway regulators, causing implantation failure and repeated miscarriages. High BCL6 levels in the uterine lining may point to possible endometriosis. 

Fact: BCL6 & Endometriosis are Connected

BCL6 & endometriosis are linked because BCL6 is a positive marker for endometriosis. Inflammation induces BCL6, which may indicate endometriosis. Endometriosis occurs when similar tissues to the uterine lining grow outside the uterus. The growth causes inflammation, scarring, and discomfort.

BCL6 controls gene expression and cell differentiation in B-cells of the immune system. That helps immune cells activate and mature. Inflammation of the uterine lining causes the immune system to reproduce more B-cells, resulting in high BCL6 levels. BCL6’s presence may indicate the possibility of endometriosis. A positive BCL6 test can assist in detecting silent endometriosis.

Myth: BCL6 Is the Only Cause of Endometriosis

BCL6 is one marker of silent endometriosis that can assist in diagnosing it, but it is not the only cause of endometriosis. Genes, hormones, and the environment may cause endometriosis. High BCL6 levels may signify the presence of endometriosis but cannot be used as a conclusive test. Endometriosis diagnosis requires clinical tests, imaging, and surgeries. 

Fact: A BCL6 Test Involves an Endometrial Biopsy

A fertility specialist can administer a BCL6 test involving an endometrial biopsy. An endometrial biopsy is a procedure that extracts cells from the patient’s uterine lining. A doctor will insert a thin, flexible tube into the patient’s cervix and use suction to remove small amounts of tissue from the uterine wall. This tissue is then examined in a laboratory for signs of inflammation or BCL6 levels. A biopsy is done around 7 to 10 days after ovulation, but the specialist will work with the patient on when they should do the test. They may also prescribe medications to facilitate the test if the patient has irregular periods. 

Fact: BCL6 Tests Are Useful in Endometriosis Treatment

A positive BCL6 test result shows one might have high BCL6 levels. It can help confirm inflamed uterine linings due to endometriosis. The scarring and inflammation of the uterine lining prevent the embryo from implanting into the uterine walls after fertilization. Failed embryo implantation can cause infertility or repeated miscarriages, affecting a woman’s reproductive outcomes. After a positive BCL6 test, reproductive specialists can suggest laparoscopy to enhance an individual’s reproductive health by removing endometrial growths.

Myth: BCL6 Testing Is Only for Older Couples

BCL6 testing can assist patients experiencing unexplained infertility, repeated miscarriages, and IVF failure to know if they have endometriosis. Women can experience fertility issues at any age based on hormonal, lifestyle, or genetic factors. A reproductive specialist may recommend the BCL6 test or other reproductive tests to assess a patient’s fertility health, depending on a patient’s health needs. 

Schedule For a Consultation Today

Repeated pregnancy losses, IVF failures, or unexplained fertility may be linked to BCL6 & endometriosis.  A positive BCL6 test result does not conclusively mean someone has endometriosis or infertility; it indicates the presence of uterine inflammation. Finding treatment fast can improve an individual’s reproductive health and the chances of having a baby. Book a BCL6 test today if you have fertility questions or concerns.