Granulation technologies and equipment are available for the production of powders into tablets and capsules. Pharmaceutical granulation helps improve flow ability, compressibility, bioavailability, and homogeneity of a drug mix.

Many pharma granulation machine techniques can produce various powder properties, such as density, particle shape and surface. When selecting the most suitable process for a drug or excipients formulation, factors like required flow and release characteristics must also be taken into account.

Wet Granulation

Wet granulation is a widely used pharmaceutical processing technique. This involves mixing dry powder ingredients with liquid binder to form granules.

Binder liquids can range from water to organic solvents such as isopropanol and ethanol, or a combination of both. When selecting a binding liquid for each material, it’s essential to select one that offers stability, efficacy and safety during granulation.

Additionally, it should be volatile enough to allow it to be dried without losing its integrity during the subsequent drying step. Furthermore, selecting an appropriate binder solution for materials which are highly compressible or porous is recommended.

Continuous granulation machine technology is becoming more and more commonplace in solid dosage form manufacturing due to its numerous advantages over traditional batch granulation techniques, including higher yields, shorter production times, and lower operational and capital expenses.

Dry Granulation

Dry granulation is a powder-based granulation process that does not involve moisture or binding solution. As such, it can be ideal for compounds which are sensitive to moisture and heat (e.g., some effervescent tablets).

The procedure begins by dispensing the API powder and excipients into a machine, then dry mixing them together for better mixing. Finally, compacting is done using roller powder compactors.

This method can be employed to manufacture a range of products, such as pharmaceutical dosage forms. It boasts several benefits like low operational costs and high product yields.

However, it’s essential to remember that this type of granulation is less popular than other processes like high shear granulation. Automating and controlling the quality can be challenging with this process, so research thoroughly before selecting it for your product. Furthermore, understanding what factors affect granulation quality is essential.

Extrusion Granulation

Granulation is an essential step in pharmaceutical manufacturing that turns fine powders into dust-free granules for various reasons. These include uniformity of API content in the final product, increased density so that blend occupies less volume per unit weight for better storage and shipment, simpler metering or volumetric dispensing, as well as improved visual appeal.

Granulation is an essential step in many pharmaceutical formulations, yet it presents manufacturers with numerous challenges. Granule production demands high standards of quality control regarding content uniformity and physicochemical characteristics such as particle size, bulk density, porosity, hardness, moisture content and compressibility as well as physical and chemical stability.

Extrusion granulation is a technique that uses an extruder with multiple shafts and/or screws to form dense pellets. It’s an efficient way to produce high-quality granules at low barrel temperatures.

Granulation technique

A pharmaceutical granulation technique that transforms cylindrical fragments into spheroids (beads or pellets) with consistent size and desirable flow characteristics. They are then further processed into capsules or tablets for further distribution.

Commonly consist of a bowl with fixed sidewalls and an oscillating friction plate that pushes the against each other and the wall. As these cylindrical fragments keep colliding against one another and the bowl wall, they gradually transform into spheres.

Spheroidal beads or pellets offer numerous advantages over conventional drug delivery systems, such as improved flow, narrow particle size distribution and superior coating characteristics. Furthermore, these particles reduce peak plasma fluctuations and side effects without reducing bioavailability.


makes the water in powder blend more cohesive as it travels across the bed of particles, enabling extradite particles to aggregate into larger sizes as they exit, thus increasing their usable yield size range.